Comprehensive Molecular Characterization of Thymic Epithelial Tumors


Chul Kim, Tolulope Adeyelu, Rohan Maniar, Alex Farrell, Jacob Zaemes, Jeffrey Solzak, Bradley Hancock, Andrew Elliott, Ida Micaily, Misako Nagasaka, Jorge Nieva, Hossein Borghaei, Balazs Halmos, Patrick Ma, Milan Radovich, Sunil Badve, Patrick Loehrer


  • Thymic epithelial tumors (TETs), which include thymomas (TMM) and thymic carcinomas (TC), are rare, yet they are the most common neoplasms in the anterior mediastinum.
  • TETs can lead to significant morbidity and mortality.
  • Thymomas are categorized into subtypes based on histological features (WHO subtypes – A, AB, B1, B2, B3)
  • To develop more effective therapeutics for TETs, it is necessary to better understand their molecular underpinnings.
  • Herein, we present the findings from an in-depth molecular characterization of TETs.
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