Characterization of the cachexia pathway in pancreatic ductal adenocarcinoma


Jingyuan Wang, Joanne Xiu, Matthew James Oberley, Francesca Battaglin, Hiroyuki Arai, Shivani Soni, Wu Zhang, Richard M. Goldberg, Anthony F. Shields, Axel Grothey, Jimmy J. Hwang, John Marshall, Igor A. Astsaturov, Benjamin Adam Weinberg, Emil Lou, Michael J. Hall, Rachna T. Shroff, Moh’d M. Khushman, Davendra Sohal, Heinz-Josef Lenz

Key Finding:

  • Molecular and clinical characterization of the myostatin-activin cachexia pathway in 9,607 PDAC tumors showed that increased pathway activation is associated with immune mediators, lipid metabolism, and inflammatory gene activation. Activators and repressors of the pathway are significant predictors of survival in PDAC, suggesting possible novel therapeutic targets.
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