Characterization of NY-ESO-1 gene expression in gastric cancer (GC)

Authors:

Annika Lenz, Jia Zeng, Joanne Xiu, Sandra Algaze, Priya Jayachandran, Shivani Soni, Jae Ho Lo, Hiroyuki Arai, Wu Zhang, Pavel Brodskiy, Pat Gulhati, Benjamin Adam Weinberg, Emil Lou, Anthony Frank Shields, Richard M. Goldberg, John Marshall, Wolfgang Michael Korn, Heinz-Josef Lenz, Evanthia T. Roussos Torres, Francesca Battaglin

Key Finding:

Gastric cancers with high expression of NY-ESO-1 have a high expression of immune related genes and a T-cell inflamed signature (TIS) score, which predicts benefit from anti-PD-1 treatment. 

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