Characterization and impact of canonical Wnt signaling pathway (WSP) alterations on outcomes of metastatic prostate cancer.

Authors:

Rana R. McKay, Julie E. McGrath, Elizabeth Pan, Alex Farrell, Himisha Beltran, Elisabeth Heath, Chadi Nabhan, Charles Ryan, Emmanuel S. Antonarakis

Key Finding:

In prostate cancer, Wnt signaling pathway alterations are enriched in metastatic tumors, and patients whose tumors harbor these alterations have a shorter overall survival following chemotherapy or hormonal therapy. 

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