Characterization and impact of canonical Wnt signaling pathway (WSP) alterations on outcomes of metastatic prostate cancer.


Rana R. McKay, Julie E. McGrath, Elizabeth Pan, Alex Farrell, Himisha Beltran, Elisabeth Heath, Chadi Nabhan, Charles Ryan, Emmanuel S. Antonarakis

Key Finding:

In prostate cancer, Wnt signaling pathway alterations are enriched in metastatic tumors, and patients whose tumors harbor these alterations have a shorter overall survival following chemotherapy or hormonal therapy. 

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