CDK4 Amplification Associated with Longer Term Response to Bevacizumab in Glioblastoma

Authors:

John Villano, Rachael Morgan, Shulin Zhang, Jill Kolesar, Joanne Xiu, Hilary Seifert, Theodore Nicolaides, Stephanie Rock, Santosh Kesari, Sonikpreet Aulakh, Eric Wong, Michael Glantz

Conclusions

  • Using a large clinical genomic database with GBM subjected to comprehensive molecular profiling, we demonstrated that amplification of CDK4 and EGFR were associated with long-term and short-term responses to bevacizumab, respectively
  • Investigation into the tumors not treated with bevacizumab suggests that CDK4 amplification may be a predictive marker for bevacizumab while EGFR amplification may be prognostic of poor survival
  • SETD2 mutations and PIK3R1 mutations are suggested to be predictive of bevacizumab benefit and prognostic of poor survival, respectively
  • This warrants further investigation in independent cohorts controlled for age and other prognostic factors. If confirmed, a genetic basis for treatment optimization may provide meaningful clinical outcomes
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