Caveolin-1: Oncogenic Role in Breast Cancer Clues from Molecular Profiling


Rebecca Feldman, Zoran Gatalica, Sandeep K. Reddy, Michael Castro, Jasgit C. Sachdev


Caveolin-1 (CAV1) is the structural component of caveolae, compartments within the plasma membrane that sequester signaling molecules, thus facilitating molecular “hot spots”. The role of CAV1 in breast cancer is an active area of investigation. We sought to understand the clinical and pathological characteristics of CAV1 positive tumors (CAV 1+) through a retrospective analysis of molecularly-profiled breast cancer patients.

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