Carcinoma of unknown primary (CUP) the role of tumor genomic profiling


Cathleen Park1, Daphne Georlette2, W. Michael Korn3, Joanne Xiu4, Hani Babiker5, Pedro Barata6, Davendra Sohal7

  • CUP is a heterogenous group of cancers characterized by early metastatic dissemination from an unknown site of origin.1
  • Overall survival is a dismal 6-12 months and untreated CUP is associated with a 4 week life expectancy.2,3
  • A 2014 review of the molecular profile of 1806 cases of CUP within the Caris Life Sciences database identified biomarkers with potential therapeutic benefits in over 96% of cases 4
  • CUP continues to be a diagnostic and treatment challenge and comprehensive genomic profiling may provide therapeutic insight.

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