Biological and prognostic relevance of epigenetic regulatory genes in high-grade gliomas (HGGs)

Authors:

Sonikpreet Aulakh, Joanne Xiu, Pavel Brodskiy, Ekokobe Fonkem, Sourat Darabi, Michael J. Demeure, Soma Sengupta, Santosh Kesari, David M. Ashley, Ashley Love Sumrall, Michael J. Glantz, David Spetzler

Key Findings: 

  • In a cohort of 1856 high grade gliomas, 181 (9.8%) displayed mutations in chromatin remodeling genes. 
  • High grade gliomas with these mutations had lower expression of immune-related genes and a colder tumor microenvironment. 
  • Patients with high grade gliomas with chromatin remodeling gene mutations had a longer overall survival when treated with temozolomide versus patients without these mutations (33 months versus 22 months, HR: 0.713, 95% CI: 0.581-0.876). 
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