Atlas of Tertiary Lymphoid Structures in Solid Tumors: Genomic Features and Prediction of Response to Immunotherapy

Authors:

A. Italiano1, J. Trent2, G. Sledge3, J. Xiu3, E. Antonarakis4, G. D'Amato5, D. Hsieh6, A. Elliott7

  • Evaluate predictive value of B cell/TLS signatures identified through RNA-seq for patient survival following immune checkpoint inhibitor (ICI) versu other therapies in solid tumors.
  • Characterize the genomic landscape (mutational status, copy number variations) of tumors enriched with B cell/TLS signatures compared to those without.
  • Compare genomic profiles (mutational status, copy number variations) between responders and non-responders to ICI therapy in B cell/TLS signature-enriched tumors.
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