Analyzing the Genomic, Transcriptomic and Immune Landscapes Associated with surface somatostatin receptor 2 (SSTR2) gene expression in Nasopharyngeal Carcinoma (NPC)


Dara Bracken-Clarke, Harris Krause, Nishant Gandhi, Phillip Walker, Minh Phan, Rusha Patel, Heloisa Soares, Emil Lou, Ari Vanderwalde, James L. Gulley, Charalampos S. Floudas

Key Findings:

  • In NPC, SSTR2 expression was positively associated with EBV positivity and with an inflamed, immunogenic tumor microenvironment.
  • Thus, in SSTR2-High NPC, immunotherapy and SSTR2-directed strategies may be appropriate therapeutic strategies. In EBV- NPC, PIK3CA-directed therapy merits further investigation.