An Analysis of Proviral Insertion Site of Moloney Murine Leukemia Virus 1 Kinase (PIM1) Expression and Clinical Outcomes in Renal Cell Carcinoma (RCC)

Authors:

S. L. Holder1, G. Lagos1, B. A. Carneiro1, A. Mega1, A. DeSouza1, R. R. McKay2, A. Elliott3, C. Nabhan3, S. L. Graff1

Conclusions:

  • Real-word data show that high PIM1 expression correlates with poorer survival in clear cell RCC but not in papillary RCC.
  • Poor survival in PIM1 high expressors appears independent of treatment received.
  • PIM1 enrichment in metastatic clear cell RCC, and the identified DEGs, suggest that PIM1 influences the extracellular matrix to promote metastases in RCC.
  • The correlation between PIM1 expression and IL-6 expression supports our data that an IL-6/JAK/STAT/PIM1 pathway is involved in clear cell RCC. Please see the companion poster at this conference: IL-6 signaling via JAK/STAT axis influences PIM1 expression in renal cell carcinoma. (K. Meza)
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