An Analysis of Proviral Insertion Site of Moloney Murine Leukemia Virus 1 Kinase (PIM1) Expression and Clinical Outcomes in Renal Cell Carcinoma (RCC)


S. L. Holder1, G. Lagos1, B. A. Carneiro1, A. Mega1, A. DeSouza1, R. R. McKay2, A. Elliott3, C. Nabhan3, S. L. Graff1


  • Real-word data show that high PIM1 expression correlates with poorer survival in clear cell RCC but not in papillary RCC.
  • Poor survival in PIM1 high expressors appears independent of treatment received.
  • PIM1 enrichment in metastatic clear cell RCC, and the identified DEGs, suggest that PIM1 influences the extracellular matrix to promote metastases in RCC.
  • The correlation between PIM1 expression and IL-6 expression supports our data that an IL-6/JAK/STAT/PIM1 pathway is involved in clear cell RCC. Please see the companion poster at this conference: IL-6 signaling via JAK/STAT axis influences PIM1 expression in renal cell carcinoma. (K. Meza)
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