With every passing day, new discoveries are made that lend support to the increasing and important role biomarker analysis and tumor profiling play in personalized cancer care. Caris Life Sciences® is actively participating in research to advance the understanding of molecular science, further enabling the delivery of precision medicine.

 

2020 Gastrointestinal Cancers Symposium (ASCO-GI)

Comprehensive molecular profiling of IDH1/2 mutant biliary cancers (BC)

Molecular characterization of appendiceal goblet cell carcinoid

Molecular landscape of gastric cancer (GC) harboring mutations of histone methyltransferases

 

2020 Genitourinary Cancers Symposium (ASCO-GU)

Pathogenic variants in PTEN to predict for increased risk of relapse and death in patients with limited stage small cell bladder cancer

 

2020 Manuscripts

Molecular Variations in Uterine Carcinosarcomas Identify Therapeutic Opportunities

Comparison of the Biomarkers for Targeted Therapies in Primary Extra-Mammary and Mammary Paget’s Disease

POT1 Mutation Spectrum in Tumour Types Commonly Diagnosed Among POT1-associated Hereditary Cancer Syndrome Families

A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients With Non-Pancreatic Neuroendocrine Tumors

Significance of Minimal Residual Disease in Pediatric Mixed Phenotype Acute Leukemia: A Multicenter Cohort Study

Comprehensive Tumor Profiling Reveals Unique Molecular Differences Between Peritoneal Metastases and Primary Colorectal Adenocarcinoma

Primary CNS lymphoma (PCNSL) commonly expresses immune response biomarkers

Immune Checkpoint Expression, Microsatellite Instability, and Mutational Burden: Identifying Immune Biomarker Phenotypes in Uterine Cancer

 

2019 American Society of Clinical Oncology (ASCO)

BRCA-mutant pancreatic cancer is associated with high tumor mutational burden (TMB) and higher PD-L1 expression

Gene mutations of SWI/SNF complex and molecular profile in colorectal cancer

Molecular differences between lymph nodes (LNs) and distant metastases (mets) in colorectal cancer (CRC)

Actionable co-alterations in breast tumors with pathogenic mutations in the homologous recombination DNA damage repair pathway

Impact of prior chemotherapy or radiation therapy on tumor mutation burden in NSCLC

DNA damage response and repair (DDR) gene mutations and correlation with tumor mutation burden (TMB) in non-small cell lung cancer (NSCLC)

Molecular landscape of colorectal cancers harboring R-spondin fusions

Molecular comparison between peritoneal metastases (PM) and primary gastric (GC) and gastroesophageal junction (GEJ) cancer

Frequency of BRCA mutation in biliary tract cancer and its correlation with tumor mutational burden (TMB) and microsatellite instability (MSI)

Molecular profiling of melanoma brain metastases (MBM) compared to primary cutaneous melanoma (CM)

Machine Learning Algorithm Analysis using 55,780 Cases from a Commercial 592-gene NGS Panel to Accurately Predict Tumor Type for Carcinoma of Unknown Primary (CUP)

Tumor mutational burden (TMB) profile of K-RAS/TP-53 co-mutation in metastatic non-small cell lung cancer (m-NSCLC)

 

2019 Gastrointestinal Cancers Symposium (ASCO-GI)

Characteristics of Colorectal Cancer (CRC) Patients with BRCA1 and BRCA2 Mutations

Association of DNA damage response and repair gene (DDR) mutations and microsatellite instability (MSI), PD-L1 expression, tumor mutational burden (TMB) in gastroesophageal cancers

Gene-specific features (MLH1, MSH2, MSH6, PMS2) of mismatch repair (MMR) protein expression and somatic mutations, microsatellite instability (MSI), and tumor mutational burden (TMB) in MSI-H and MMR-mutated tumor genomic profiles

Comprehensive molecular profiling of signet-ring-cell carcinoma (SRCC) from the stomach and colon

 

2019 Genitourinary Cancers Symposium (ASCO-GU)

Molecular Profiling of Aggressive Variant Urothelial Carcinoma

Non-urothelial bladder cancer genomic alterations and patient outcomes

 

2019 International Association for the Study of Lung Cancer (IASLC)

Spectrum of EGFR exon 20 insertion mutations and co-occurring genetic alterations in patients with non-small-cell lung cancer

 

2019 Society of Gynecologic Oncology (SGO)

Comprehensive molecular profiles of low-grade serous ovarian cancer

Molecular portraits of clear cell ovarian and endometrial carcinoma with comparison to clear cell renal cell carcinoma

Comprehensive genomic profiling of mucinous ovarian carcinoma with comparisons to mucinous colorectal carcinoma

 

2019 Society of Neuro-Oncology (SNO)

Mutations of H3.3 and H3.1 in a large cohort of gliomas

Understanding the differences in adolescent and young adult (AYA) gliomas and older adult (OA) gliomas based on functional molecular subgroups

 

2019 San Antonio Breast Cancer Conference (SABCS)

Prevalence of Phosphatidylinositol-3-Kinase (PI3K) Pathway Alterations and Co-Alteration of Other Markers in Breast Cancer

Somatic Genomic profiles of Breast Tumors Differ by BRCA1 and BRCA2 Variants of Unknown Significance Status

 

2019 European Society for Medical Oncology (ESMO)

Large-scale Analysis of CDH1 mutations define a distinctive molecular subset in gastric cancer

Comprehensive molecular characterization of brain metastases (BM) from colorectal cancer (CRC)

Comparative molecular analyses between microsatellite stable BRAFV600E mutant colorectal cancers and BRAFV600E mutant melanomas

WRN mutated Colorectal Cancer (CRC) is characterized by a distinct molecular and immunological profile

Comparison of the Biomarkers for Targeted Therapies in Primary Extra-Mammary and Mammary Paget’s Disease

 

2019 Manuscripts

Molecular Profiling of Appendiceal Adenocarcinoma and Comparison with Right-sided and Left-sided Colorectal Cancer

Detection of NRG1 Gene Fusions in Solid Tumors

Impact of Patient Age on Molecular Alterations of Left-Sided Colorectal Tumors

Clinical, Pathological and Molecular Profiling of Radioactive Iodine Refractory Differentiated Thyroid Cancer

The current state of molecular testing in the treatment of patients with solid tumors, 2019

Tumor Mutational Burden Is Site Specific in Non–Small-Cell Lung Cancer and Is Highest in Lung Adenocarcinoma Brain Metastases

Molecular profiling of biliary cancers reveals distinct molecular alterations and potential therapeutic targets

EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex

 

2018 American Society of Clinical Oncology (ASCO)

Pathogenic somatic mutation (SM) of mismatch repair (MMR) genes and associations with microsatellite instability (MSI), tumor mutational burden (TMB) and SM in other DNA repair pathways in 24,223 tumor genomic profiles

Circadian clock gene PER1 mutations in colorectal cancer (CRC)

Incidence of Neuregulin1 (NRG1) gene fusions across tumor types

Comprehensive molecular profiling of paired patient samples of primary and metastatic (met) pancreatic ductal adenocarcinoma (PDAC)

Molecular Analyses of Left- and Right-Sided Tumors in Adolescents and Young Adults (AYA) with Colorectal Cancer (CRC)

Molecular characterization of appendiceal cancer and comparison with right-sided (R-CRC) and left-sided colorectal cancer (L-CRC)

Comprehensive genomic profiling of 724 gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

Impact of MLH1, PMS2, MSH2 and MSH6 alterations on tumor mutation burden (TMB) and PD-L1 expression in 1,057 microsatellite instability-high (MSI-H) tumors

Mutational Complexity Increases in Lung Adenocarcinoma (LADC) with the Development of Brain Metastasis (BM)

Multi-omic Profiling of Metastatic Lesions to Guide Treatment Selection: The Side Out 2 Trial Experience Associations of age, PD-L1 status, BRAF mutation and TMB in advanced melanoma


2018 Gastrointestinal Cancers Symposium (ASCO-GI)

Molecular Characterization of Intestinal and Diffuse Types of Gastric Cancer

Differences in Molecular Profiles of Males and Females with Colorectal Cancer (CRC)

 

2018 Gastrointestinal Cancers Symposium (ASCO-GU)

Molecular profiles of small cell bladder and prostate cancer, comparisons with small cell lung cancer

A Phase II Trial of Risk Enabled Therapy After Initiating Neoadjuvant Chemotherapy for Bladder Cancer (RETAIN BLADDER)

 

2018 Society of Gynecologic Oncology (SGO)

Molecular Variations in Uterine Carcinosarcomas: Are There Therapeutic Opportunities?

Mutational burden, tumor PDL-1 expression, and microsatellite instability in gynecologic malignancies: Implications for immune therapy

Immune checkpoint expression, microsatellite instability, and mutational burden: Identifying immune biomarker phenotypes in uterine cancer

Distinct molecular profiles and potential therapeutic targets in androgen receptor stratified ovarian cancer patients

 

2017 American Society of Clinical Oncology (ASCO)

Impact of patient age on molecular alterations in left-sided colorectal tumors

Molecular profiling comparison of breast cancer subtypes in young women and older women

Variable DNA mismatch repair associated gene profiles in colorectal versus uterine cancers

Characterization of Tumor Mutation Load (TML) in Solid Tumors

Distribution of Receptor Tyrosine Kinase (RTK) nsSNPs in Breast Cancer (BC) Patients using Next-Generation Sequencing (NGS)

Spectrum of Tumor Mutational Load in Genitourinary Cancers

Colorectal cancer: impact of primary tumor location on genetic alterations

Prevalence of Homologous Recombination Deficiency (HRD) Among All Tumor Types

Localization of Non-Receptor Tyrosine Kinase (nRTK) Variants in Solid Tumor Patients Using Next-Generation Sequencing (NGS)

RNASeq Analysis of Glioma Tumors reveal Targetable Gene Fusions

 

2017 Gastrointestinal Cancers Symposium (ASCO-GI)

Molecular Variances Between Rectal and Left Sided Colon Cancers

Molecular characterization of squamous cell carcinoma of the anal canal (SCCA)

Molecular characterization of early vs. late onset gastroesophageal cancer

Characterization of Tumor Mutation Burden (TMB) in Gastrointestinal (GI) Cancers

 

2017 Manuscripts

Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy

Comparative molecular profiling of HPV-induced squamous cell carcinomas

BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations

 

2016 American Society of Clinical Oncology (ASCO)

Comparative molecular analyses of BRAF-V600E mutant tumors: Colorectal cancers (CRC) vs. melanomas

Comparative molecular analyses of colon versus rectal tumors

Ras family mutation patterns in a large cohort of CRCs

Comparative molecular analyses of esophageal cancer: Adenocarcinoma vs. squamous cell carcinomas and impact on outcome

Panomic assessment reveals DNA repair alterations are common in prostate cancer (PC) and predicts potential therapeutic response to taxane-platinum combination therapy

Differences in the molecular landscape of cancer between African American (AA) and Caucasian (CC) cancer patients

Novel panomic validation of time to next treatment (TNT) as an effective surrogate outcome measure in 4,729 patients

Comparative molecular analyses of pancreatic cancer (PC): KRAS wild type vs. KRAS mutant tumors and primary tumors vs. distant metastases

Distribution of PD-L1 expression in diverse cancer types: Experience with over 10,000 cases 

Fusion Analysis of Solid Tumors Reveals Novel Rearrangements in Breast Carcinomas

Tumor profiling of liver metastases (LM) from CRC, NSCLC, pancreatic (PC), breast (BC) and gastroesophageal (GE) tumors to reveal differences versus primary tumors including in cMET, MYC, CDK4, Her2, b-catenin and PD1

 

2016 Gastrointestinal Cancers Symposium (ASCO-GI)

Molecular characterization of colorectal tumors in young patients compared with older patients and impact on outcome

 

2016 Genitourinary Cancers Symposium (ASCO – GU)

Molecular profiling of non-urothelial bladder cancer: adenocarcinoma and squamous cell carcinoma 

 

2016 American Association for Cancer Research  (AACR)

Multiplatform molecular profiling of invasive lobular breast cancer 

Molecular and genomic characterization of SCLC 

Clinico-pathological and molecular features associated with TP53 mutation in 3457 molecularly-profiled colorectal cancers (CRCs)

Frequent BRCA2 somatic mutations in colorectal cancer patients with mircrosatellite instability (MSI)

Mutations on the homologous recombination pathway in 13 cancer types

Expression of class III beta-tubulin (TUBB3) in 3580 colorectal cancers (CRCs) and correlation with clinico-pathological and molecular features

A rationale for treatment of colorectal cancer with mitomycin C and crizotinib 

Analysis of MET-amplified solid tumors using chromogenic in situ hybridization (CISH)

 

2016 San Antonio Breast Conference (SABCS)

Racial differences in the molecular landscape of breast cancer

Programmed death 1 (PD-1) and PD-1 ligand (PD-L1) distribution in triple negative breast cancer TNBC

ESR1 mutations, ESR1 fusions and co-occurring alterations assessed in breast cancer tumors

 

2016 Society for Neuro-Oncology (SNO)

Medulloblastoma candidate pathways for novel treatment strategies

Novel targets in ependymal tumors

PD-1,PD-L1 and genomic expression profiling of meningiomas 

 

2016 Manuscripts

Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies

Identification of molecular targets in vulvar cancers