Caris Life Sciences’ scientific experts and external collaborators are contributing to major advances in the understanding of blood-based circulating microvesicles (cMV) and their potential utility to aid in the diagnosis, prognosis, and theranosis of cancer and other complex diseases. Posters and abstracts highlighting the promise of ADAPT Biotargeting Systemâ„¢ are listed below.

  • Caris will deliver 10 poster presentations at the 2016 American Association for Cancer Research (AACR) Annual Meeting from April 16-20, in New Orleans, La., including one late-breaking poster presentation. See what others said about AACR this year on Twitter.

    Adaptive dynamic artificial poly-ligand targeting (ADAPT) enables plasma-based exosome profiling with potential diagnostic utility (Late-Breaker)

    Multiplatform molecular profiling of invasive lobular breast cancer

    Analysis of MET-amplified solid tumors using chromogenic in situ hybridization (CISH)

    Molecular and genomic characterization of SCLC

    Clinico-pathological and molecular features associated with TP53 mutation in 3457 molecularly-profiled colorectal cancers (CRCs)

    Frequent BRCA2 somatic mutations in colorectal cancer patients with mircrosatellite instability (MSI)

    Mutations on the homologous recombination pathway in 13 cancer types

    Caveolin-1: Beyond a marker for basal-like breast cancers

    Expression of class III beta-tubulin (TUBB3) in 3580 colorectal cancers (CRCs) and correlation with clinico-pathological and molecular features

    A rationale for treatment of colorectal cancer with mitomycin C and crizotinib

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  • ADAPT Aptamer-based profiling of liquid biopsies to improve the accuracy of breast cancer diagnoses in women with dense breast tissue

    Biomarker comparison between androgen receptor positive-triple-negative breast cancer (AR + TNBC) and quadruple-negative breast cancer (QNBC)

    Distinct biomarker features in triple-negative breast cancer metastases to the brain, liver, and bone

    Molecular profiling comparison of BRCA1/2-mutated and BRCA1/2 non-mutated triple-negative breast cancer (TNBC)

    Comprehensive profiling of metaplastic breast carcinoma reveals frequent over-expression of PD-L1

    Multiplatform molecular profiling identifies potentially targetable biomarkers in malignant phyllodes tumors of the breast

    ABC Transporter Expression: Clues into Chemoresistance of Triple Negative Breast Cancers

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  • Circulating Microvesicles Contain Critical Elements of the RISC Complex

    Effect of Colonoscopy on Circulating Microvesicles

    Identification and Implications of Transcription Factors in Circulating Microvesicles From Cancer Patients

    Multicolor Flow Cytometric Analysis of Cancer-Derived Microvesicles Reveals a Unique Subpopulation Ratio in Plasma From Prostate Cancer Patients

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  • GW182 Associates With Circulating Microvesicles in Human Plasma

    Differential Protein Expression and miR Content of Sorted Subsets of Circulating Microvesicles From Cancer Patients and Health Controls

    A Novel Blood-Based Method of Evaluating KRAS in Circulating Microvesicles From Colorectal Patients

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  • Analysis of a Circulating Microvesicle-Based Assay in At-Risk Patients for the Detection of Prostate Cancer

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